Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Physical aim and pharmacology away from curcumin
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the big part of the brand new reddish color out of turmeric, a keen Indian liven that is taken from brand new rhizome of your warm plant Curcuma longa, and therefore is one of the Zingiberaceae family members. Within this section, we talk about the pharmacological products out-of curcumin and mention this new molecular basics for these factors. I then opinion the proven and you may prospective medical spends off curcumin. Curcumin known usually just like the a restorative broker, but its apparatus out of action is actually detailed. The fresh new pharmacological effects of curcumin be seemingly the consequence of good synergism from companies regarding weakened biochemical interactions with multiple biological plans into the interconnected signaling pathways. Such goals become enzymes such as for example cyclooxygenase, lipoxygenase and you may healthy protein kinases, and transcription things for example NF-?B, STAT and you can Nrf2. Modulation of these particles has an effect on downstream affectors that make the newest antiinflammatory, antioxidant, chemopreventive, anticancer, and you can antimicrobial points out of curcumin. These consequences was basically tested for the health-related examples of curcumin having aches and you will inflammatory problems, cancers, Alzheimer condition, cardiovascular diseases, and you will all forms of diabetes. The latest examples have used adjustable dosages out-of curcuminwith various other frequencies and you will cycle, into the standard achievement one to higher doses from curcumin on number of g have to receive healing consequences. Read more
Curcumin: Synthesis, Emerging Part in the Pain Management and you may Wellness Effects
Book Section Samples of plant-derived pharmaceuticals with get to be the appeal out of continued and you may great search and invention notice enjoys, yet, come a little scarce. Immediately after several years, the past two decades were described as a beneficial 100-fold increase in the amount of scientific stuff wrote a year you to is actually out-of relevance to the entry to curcumin during the biomedicine. Find out more
Structure, synthesis and you will physical factors from curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many prospective pharmacological effects and could has therapeutic software a number of problem says, due to the fact talked about in detail in the earlier part. However, the possibility scientific effectiveness out-of curcumin is bound by the its physicochemical services regarding poor water solubility and you can imbalance, and therefore bring about reduced bioavailability. Prodrugs regarding curcumin promote a way to improve of the biopharmaceutical and you may pharmacokinetic features, and will ensure it is exploitation of your pharmacological ramifications of curcumin. Contained in this chapter, i first review this new physicochemical and pharmacokinetics off curcumin. I then describe the design of curcumin prodrugs which have increased water solubility and you may increased chemical compounds balances that can easily be converted returning to 100 % free curcumin abreast of bioactivation in vivo. I emphasize recent achievements in this area, that have a focus on the build, synthesis and you will evaluation away from prodrugs according to promoieties and amino acids, essential fatty acids, nucleic acids https://worldbrides.org/blog/europaeiske-kvinder-vs-japanske-kvinder/, dicarboxylic acids, and you will polymeric material for example hyaluronic acidic and polyethylene glycol. This section has got the basis for optimization of the physicochemical and you can biopharmaceutical qualities as well as the biological items from curcumin prodrugs, on the goal playing with ones curcumin types during the medical apps. Find out more
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